Originally developed as a treatment for managing blood glucose (sugar) levels in people with type 2 diabetes, Ozempic has seen a surge in popularity among people in pursuit of weight-loss solutions.
Key Facts
- Ozempic has shown significant results in clinical trials with an average weight loss of about 15 percent of body weight.
- The drug works by increasing insulin sensitivity, suppressing appetite, and slowing digestion, contributing to its effectiveness in weight management.
- However, weight tends to be regained if the medication is discontinued.
- Common side effects include gastrointestinal issues and more severe risks like thyroid tumors and pancreatitis, making it important to consult with your healthcare provider before starting Ozempic.
What is Ozempic?
Ozempic, with the active ingredient semaglutide, is part of a class of medications known as GLP-1 agonists.
Marketed under various brand names, including Ozempic for type 2 diabetes and Wegovy for weight management, this medicine is a product of the pharmaceutical company Novo Nordisk.
Approved by the U.S. Food and Drug Administration (FDA) in 2017 for type 2 diabetes management, Ozempic is a once-weekly injectable medication designed to improve blood sugar levels and A1c (a measure of glucose control over the previous 2 to 3 months) in adults.
Can Ozempic help you lose weight?
While it is approved to regulate blood sugar in people with type 2 diabetes, Ozempic is also recognized for its weight-loss benefits.
This has led to its “off-label” (not approved by the FDA) use for weight management in people who are overweight or obese.
In a significant development, the FDA approved a different formulation of semaglutide, branded as Wegovy, in June 2021 specifically for weight management in adults and certain adolescents who are overweight or obese and have at least one weight-related condition like hypertension (high blood pressure), high cholesterol, or type 2 diabetes.
Learn more about the similarities and differences between these medicines in: Ozempic vs. Wegovy — Which Drug Is Right for You?
Additionally, Ozempic and similar GLP-1 agonists have found off-label use in managing type 1 diabetes, with some people experiencing notable weight loss under careful medical supervision.
“I don’t experience vicious high blood sugars as often now, and when I do, they are less ‘sticky’ — they don’t stay high for as long, and the crash down isn’t as severe.“
Stevie Cook, T1D (read about Stevie’s experience with Ozempic)
Research on Ozempic for weight loss
Research reinforces the weight loss potential of semaglutide, with participants experiencing significant reductions in body weight over time when combined with lifestyle modifications.
For instance, over a 68-week period in one study, trial participants using Ozempic reported an average weight loss of 10 to 15 percent, compared to a 2 percent loss in the placebo (inactive treatment) group. However, it’s important to note that weight tends to be regained if the medication is discontinued.
Another two-year study showed similar results, with participants on semaglutide losing an average of 16.7 percent of their total body weight versus 0.6 percent with placebo.
Those taking semaglutide were also much more likely to lose at least 5 percent of their body weight, with nearly 84 percent of those on the medicine losing at least that much weight.
Yet more data from the SURE Denmark/Sweden study showed not only statistically significant weight loss among participants using semaglutide but also improved A1c levels as well.
These findings highlight the effectiveness of semaglutide in weight loss. The decision to use this medication, however, should be made in consultation with a healthcare provider, considering its originally intended use and your overall health.
What are the side effects?
Ozempic can cause side effects ranging from common gastrointestinal issues to more serious conditions such as thyroid tumors and pancreatitis.
Immediate medical attention is recommended for severe reactions.
The medication is not advised during pregnancy or breastfeeding.
Speak with your medical team before starting Ozempic to determine if this medicine is right for you.
For a more comprehensive exploration of the potential adverse effects, read: Ozempic Side Effects.
Who should not take Ozempic?
Only take Ozempic if it has been prescribed by your medical team. Ozempic is typically prescribed for people managing type 2 diabetes, especially those dealing with insulin resistance.
The off-label use of Ozempic for weight loss has contributed to a national shortage, impacting those who need it for diabetes management.
Although not FDA-approved for type 1 diabetes, Ozempic may be prescribed off-label for this condition if you’re experiencing high blood sugar levels and insulin sensitivity issues.
Using Ozempic does not eliminate the need for insulin therapy.
Ozempic is contraindicated (not advised) during pregnancy. If you become pregnant while on Ozempic, you’ll need to discontinue its use.
Avoid Ozempic if you have a personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2).
Do not use Ozempic if you are allergic to semaglutide or any of its components. Always share your full medication list with your doctor before beginning Ozempic.
While Ozempic is generally safe for many people, it should be approached with caution in people with a history of pancreatitis or serious hypersensitivity reactions to semaglutide.
Additionally, those undergoing active treatment for diabetic retinopathy (damage to the retina of the eye) should speak with their healthcare provider, as Ozempic might have an impact on the progression of diabetic eye diseases.
tony williams
I was diagnosed with Diabetes II a dozen years ago. A multitude of medications, I changed my diet, I was already walking and exploring our deserts and mountain, so exercise was not an issue.
The diagnosis came about when the KP checked my ancestry and found Mexican ancestors and American Indian ancestors, the Germans were discounted.
So the numbers kept climbing till they matched the diagnosis.
Left the KP, and went to what I believe is a better facility that works with all data, not just the Cherry Picked type.
Now, to the Ozempic.
Once a week, 0.25, had side effects, they became liveable.
Then to 0.500 dose. Side effects came back, plus I began to eat less. Yeppers, the system was slowed down, big time.
My numbers BS, aka Blood Sugar, came down. Yay!
My weight decreased slightly, itty bitty amount, but, a long journey begins with a single step.
I am still just down 20 pounds over a year, 10% of total weight.
Numbers are rarely bad, only when steroids needed to calm down other issues I was born with.
My pants are falling down, need suspenders & belts. Same weight, gut size decreased.
I am fine, in my opinion. The fat blobs are turning back into muscle. I never expect to reach the fitness of my youth. ut if it is muscle, it will assist in the using of BS.
I still want to loose another 15~20 pounds. I expect the Oxempic is doing its job. Now I need to do mine.
Jennifer Flick
In short, YES!
If you have gastro symptoms, you’re overdosed. Back down until symptoms abate, then gently raise as needed.