Ozempic is one of the many injectable diabetes medications on the market today. While it’s similar to others on the market, it offers several unique details, too.
In this article, we’ll look at how Ozempic works, who can take it, and the most common side effects.
Table of Contents
What is Ozempic?
Semaglutide — known under the brand name Ozempic and manufactured by Novo Nordisk — is a glucagon-like peptide 1 (GLP-1) agonist. This drug category is also referred to as an incretin mimetic, which means it mimics the other hormones in the body that help regulate blood sugar levels.
Taken via injection once per week, Ozempic works to improve your blood sugar in several ways:
- Increases your body’s natural insulin production
- Reduces your appetite which can lead to weight-loss
- Reduces the amount of glucose produced by your liver
- Delays the emptying of food from your stomach into the small intestine
For many people with type 2 diabetes, your body may actually struggle to naturally produce enough of this hormone which leads to a cycle of overeating which further worsens insulin resistance, blood sugar levels, and weight-management struggles.
In a clinical study, Ozempic reduced the patient’s A1c by 1.4 to 1.6 percent after 30 weeks of treatment. It also reduced fasting blood sugar levels by 41 to 44 mg/dL over that time period.
Who can take Ozempic?
Ozempic is only recommended for people living with non-insulin-dependent diabetes (typically type 2 diabetes). Ozempic is not a substitute for insulin and is not approved for use in patients with type 1 diabetes.
Ozempic is not recommended as the first pharmaceutical treatment you try as a person with type 2 diabetes. Instead, medications like Metformin would be used first, and Ozempic could be an eventual choice if other options aren’t effective.
The dosage of Ozempic should start small and be increased gradually to the full dose over the course of 4 weeks. This should be managed closely by your healthcare team.
If you miss a dose, talk to your doctor as soon as you realize. Depending on how many days it’s been since your missed dose, you may be able to take it as soon as you remember. If it’s too close to your next Ozempic dose, you may be advised to wait until your next dose.
You should talk to your doctor before taking Ozempic if
- You have a history of problems with your pancreas or kidneys
- You have a history of diabetic retinopathy
- You are pregnant or plan to become pregnant soon
- You are breastfeeding
You shouldn’t take Ozempic if
- You have a history of pancreatitis
- You are under 18 years old
- You have a history of thyroid tumors or thyroid cancer
- You or a family member have ever had MTC or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)
FDA-approved to treat obesity, even in those without diabetes
Initially intended for people with type 2 diabetes, Ozempic has gained a reputation in helping those struggling with obesity, too.
In a study with almost 1000 participants, all of whom had a body mass index of 30 or higher but did not have diabetes, Ozempic led to weight loss in 65 percent of participants compared to only 34 percent of participants taken liraglutide (Victoza).
“This randomized study of weight loss induced with semaglutide in people with obesity but without diabetes has shown the highest weight reductions yet seen for any pharmaceutical intervention,” said study author Patrick M. O’Neil, Ph.D., director of the Weight Management Center in South Carolina.
While it’s similar to Trulicity (dulaglutide, manufactured by Lilly), Ozempic is the first GLP-1 drug approved for use in patients with obesity even if they do not have type 2 diabetes.
Always consult your healthcare provider before taking Ozempic. Ozempic should NOT be used as a weight-loss drug without medical supervision.
Common Ozempic side effects
According to the manufacturer, the most common and most harmless side effects of Ozempic include:
- Nausea
- Vomiting
- Diarrhea
- Abdominal pain
- Constipation
These side effects are directly related to the drug’s impact on your stomach’s rate of digestion which benefits your blood sugars.
Serious (less common) Ozempic side effects
- Thyroid tumors — possibly cancerous
- Swelling in your neck
- Hoarseness in throat
- Difficulty swallowing
- Shortness of breath
- Pancreatitis
- Pain in your abdomen or back
- Changes in your vision
- Tell your healthcare team immediately
- Low blood sugar
- Discuss this with your doctor to adjust the dosage or other meds
- Worsened kidney issues and kidney failure
- Serious allergic reaction
- Itching
- Rash
- Difficulty breathing
The concern regarding thyroid tumors is based on the results of Ozempic and similar medications in rats and mice. Some rats and mice developed thyroid tumors, some of which were cancerous. It’s not known if Ozempic has this effect in humans.
Interested in using Ozempic for your own diabetes management? Talk to your doctor to determine whether this might be an appropriate medication for you.
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I am on Ozempic and I was started slowly with .25 mg for four weeks then .50 mg for four weeks then now on the full 1 mg. The nausea was mild and I have lost some weight but because I feel full, not from the nausea. All of the people I have spoken to that couldn’t tolerate Ozempic were started on a higher dose so it’s no wonder they had such awful nausea. I hope those having this problem can try increasing the dose more slowly.
I took ozempic and actually lost 8 pounds in 7 days due to the fact that I couldn’t eat from the nausea. It was the worst week of my life, followed by the 2nd worst week of my life. It’s been over a month since I took it and I still can’t eat certain foods without getting nauseous.
Hello, I just started taking the Ozempic, I lost 5 lbs in my first week. How much total weight have you lost in the month of being on the med? The nausea is horrible I’ve only taken two injections, but will continue my journey. I am also type 2 diabetic.
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