For many adults with type 2 diabetes, Mounjaro is an excellent option to help manage blood sugar levels and improve A1c.
There are different doses available. Yours will depend on your health history, health goals, lifestyle, and weight.
Figuring out how much Mounjaro to take can take time, and it should always be a decision made jointly with your doctor.
This article will explain everything you need to know about Mounjaro dosing.
Table of Contents
- What dose do you typically start with?
- What is a normal Mounjaro dose?
- How and when can you increase your dose?
- What is the right dose for me?
- What is the right dose for weight loss?
- What happens if I stop taking Mounjaro?
- Are there different Mounjaro pens?
- What is the strongest Mounjaro?
- What do I do if I forget to take my dose?
- Can you overdose on Mounjaro?
- How do I store Mounjaro?
- Final thoughts
What dose do you typically start with?
If you’re new to Mounjaro (tirzepatide), your doctor will want to start you on a low dose.
This is because Mounjaro may cause adverse side effects, including nausea, vomiting, diarrhea, constipation, low blood sugar, and decreased appetite.
These symptoms usually go away after a few weeks of starting the drug, but taking a lower dose when you begin treatment can help prevent them altogether.
According to the manufacturer, a typical starting dose is 2.5 mg, taken once per week. This amount doesn’t affect blood sugar levels, but it does help your body get used to the medicine. The drug is taken as an injection just under the skin.
If you’re seeing improvements in blood sugar levels and insulin resistance without adverse side effects, your doctor may increase your dose after the first four weeks.
What is a normal Mounjaro dose?
There is no “normal” dose of Mounjaro because everyone is different.
But there are specific increments that people take Mounjaro in. They are as follows:
- New to treatment: 2.5 mg once per week for the first four weeks
- Ongoing treatment: 5+ mg once per week starting on week five
If your blood sugar levels are still not under control with 5 mg once weekly, your doctor may increase your dose.
How and when can you increase your dose?
You most likely will not be able to increase your initial dose until after you’ve been on the medication for at least four weeks.
At week five, your doctor may advise you to double your dose to 5 mg for four additional weeks.
You should closely monitor your blood sugar levels and note any adverse side effects when increasing your dose, as this is when you’re most likely to experience symptoms such as nausea, vomiting, and diarrhea.
Get a more detailed overview in: Mounjaro Side Effects: What You Need to Know.
If you’re tolerating 5 mg well and not seeing improvements in blood sugar management, your doctor may advise an additional increase.
If you require a larger dose, your doctor may increase your medication to either 7.5 mg, 10 mg, 12.5 mg, or 15 mg taken once a week as your maintenance dose.
Note that each increase will require a new prescription because each larger dose comes in a bigger dosing pen.
Doses should not be increased by more than 2.5 mg every four weeks.
Learn more about how to take the medicine in: Mounjaro Injection: Where and How to Inject.
What is the right dose for me?
You and your doctor will determine your dose.
It may vary based on your health history, health goals, lifestyle, height, weight, level of insulin resistance, diet, and daily activity level.
Higher doses will yield more results such as lower blood sugar levels, weight loss, and improved A1c levels (a measure of glucose control over the previous 2 to 3 months).
However, the higher the dose, the more likely you are to experience adverse side effects.
Keep this in mind as you scale up your doses, and only ever do so under the guidance of your doctor.
Never take more Mounjaro than you’ve been prescribed.
What is the right dose for weight loss?
Mounjaro is not approved by the U.S. Food and Drug Administration (FDA) as a weight-loss medicine.
However, the FDA has approved a sister drug called Zepbound for weight loss based on clinical research supporting this outcome. (Zepbound is the same medicine as Mounjaro at the same strength, but with a different name for use as a weight-loss treatment.)
Zepbound is approved for use in overweight or obese adults with at least one weight-related condition.
The FDA’s approval of the medicine was based primarily on the results from two trials.
Read more in: Can Mounjaro Help You Lose Weight?
What happens if I stop taking Mounjaro?
Do not stop taking any diabetes medications without the guidance of your doctor.
After stopping Mounjaro, many people will regain lost weight and may experience higher blood sugar levels from increased insulin resistance and hunger.
If you wish to stop taking Mounjaro, your doctor will likely taper your dose to lessen the side effects as the medication leaves your system.
Talk with your doctor if you are experiencing severe negative side effects, Mounjaro doesn’t fit into your lifestyle, or your health insurance doesn’t cover the medication.
Are there different Mounjaro pens?
Mounjaro is available in six different dosing pens. They come in the following variations:
- 2.5-mg pen
- 5-mg pen
- 7.5-mg pen
- 10-mg pen
- 12.5-mg pen
- 15-mg pen
Each pen is prefilled with a single dose. The pens come in different colors depending on the dose they contain.
For a 30-day prescription, you will receive four pens in your prescribed dose.
This makes overdosing on the medication less likely.
If and when you’ve been prescribed a larger dose, you will need a new prescription each time your dose goes up.
What is the strongest Mounjaro?
All of the Mounjaro pens contain the same active ingredient — tirzepatide. The larger dosing pens do not have a more potent drug formulation.
When people increase their dose of Mounjaro, they simply increase the amount they take per week.
What do I do if I forget to take my dose?
Remember to take your Mounjaro on the same day each week, at generally the same time (for example, over breakfast). There is no best time of day to administer the medicine — you can do so at whatever time works best for you.
The medicine is given as a shot into the fatty part of the skin on the top of the thigh, belly area, or upper arm. Make sure to rotate the injection site each time to help prevent skin irritation and improve absorption.
If you miss a dose of Mounjaro, take it as soon as possible within four days of your missed dose.
If you miss a dose for more than four days, skip that week and resume taking your Mounjaro on your regular schedule the following week.
Do not take two Mounjaro doses within three days of each other.
Missing one dose will not significantly affect your blood sugar levels or insulin resistance, and it won’t make you gain weight.
Can you overdose on Mounjaro?
Yes. If you overdose on Mounjaro, you may experience severe side effects, including nausea, vomiting, and low blood sugar, which can be fatal (especially if you’re also on insulin).
Monitor for signs and symptoms of extremely low blood sugar that include:
- Dizziness
- Confusion
- Increased heart rate
- Shallow breathing
- Shakiness
- Grogginess
- Fatigue
- Unconsciousness
Seek emergency medical attention immediately if you suspect you’ve overdosed on Mounjaro.
How do I store Mounjaro?
Store your medicine at a temperature between 36 to 46 degrees Fahrenheit (2 to 8 degrees Celsius).
Ensure that it gets no hotter than 86 degrees Fahrenheit (30 degrees Celsius).
Never freeze your Mounjaro pens.
The medication can be left unrefrigerated for up to 21 days if the temperature never exceeds 86 degrees Fahrenheit (30 degrees Celsius).
Keep your pen in its original casing to protect it from sunlight.
Final thoughts
It is important to remember that Mounjaro’s effectiveness and safety are closely tied to the correct dosing, which varies from person to person.
Starting with a lower dose helps in minimizing side effects, with gradual increases made as needed based on individual response and tolerance. This personalized approach ensures that each person receives the maximum benefit while maintaining safety.
It’s also important to emphasize that Mounjaro is not a one-size-fits-all solution and should be part of a broader health management plan that includes diet, exercise, and regular medical consultations.
While the prospect of weight loss may be appealing, you should focus on the primary goal of Mounjaro: managing blood sugar levels effectively.
Any treatment changes, whether dose adjustments or discontinuation, should always be made under the guidance of a healthcare professional to ensure the best outcomes.
Suggested next article: Everything You Need to Know About Mounjaro.
Howard
Using 7.5 for 18 months, lost 30 lbs, a1c fell to 6.1, now 18 months later a1c increased to over 7.1.
MD wants to increase dose / should I?!!
Christel Oerum, MS
I would if your doctor recommends it. You can always as questions. Get a clearer picture from your doctor on potential side effects and upside. And also talk over alternatives or what to do if a higher does doesn’t work for you
Michael Oleksiuk
“According to the manufacturer, a typical starting dose is 2.5 mg, taken once per week. This amount doesn’t affect blood sugar levels,…” this was not true for me. I have seen my average morning fasting blood sugar go from 200 to 125 starting with the first 2.5mg dose. And stayed in the 120s for 3 weeks and still counting. I may try to stay on the 2.5 mg dose for the next 4 weeks.
Brooke
I agree, my blood sugar responded almost immediately with the 2.5mil. I love this stuff🤗
Nancy Eisele
I have now not had my Rx of Mounjaro for 3 weeks due to availability. What exactly will this do to me. My doctor and all the pharmacies have no answers. Your put on something and then it is not available for a health need and no one has any response.
Christel Oerum, MS
It takes about 25 days for Mounjaro to completely leave your system. If you can’t get it, your doctor should start you on another medication so you won’t end up seeing your blood sugars shoot up
Darren Ingram
My solution to the shortage: I currently take 10mg of Mounjaro, however, I also had my doctor prescribe 7.5mg, midway through the 10mg prescription. When I run out of the 10mg prescription and must wait 3-4 weeks for a refill, I always have the 7.5mg Mounjaro as a backup. So far, I have not run into an availability issue, as I always have one or the other, either the 10mg or 7.5mg.
Laura B Dell
I am unable to find a supply of either 2.5 or 5mg of Mounjaro. Where can I find it? When will it be available?
Christel Oerum, MS
It’s frustrating, to say the least. Aside from calling all of your local pharmacies or seeing if you can have it shipped to you, there isn’t much more you can do
Cheryl leith
I was using Mounjaro with good results. A1C, 5.7. I was up to 15mg. Due to the unavailability, I have missed two weeks. Now, I’m telling my dr. to D/C the order, I’m not playing that game with my diabetes. It’s great when new products are made available, but getting used to it, and having it to work, then BAM, Oh we can’t get it ! Not for me !
Sandra Vega
I Have lost over 30lbs, since starting Mounjaro in January 2024, this is including diet change and adding exercise. I was just increased to 15mg, can’t wait to see the health benefits it brings me. I do my injections on my stomach about 3 inches from the bellybutton, on the same day and time every week. So far this has been a blessing controlling my blood sugars.
Diana Quesenberry
These injections really hurt in my opinion,they need a better design
Martin Keller
I have only lost 6 pounds over the past 2 months on mounjaro. I was initially on 2.5 mgm for a month and then 5 mgm for a month, with an hour of exercise daily (swimming); and good nutrition. I do not have any side effects. Is it okay to use a 5 mgm and a 2.5 mgm pen to increase to 7.5 mgm, if my physician wants me to increase my dose to 7.5 mgm, and I still have 2.5 mgm and 5 mgm pens that I have not used?